Wahrnehmungen von Pflegenden im Bereich der Intensivpflege während der COVID-19-Pandemie.

Unlabelled: Perceptions of intensive care nurses during the COVID-19 pandemic - A qualitative survey Background: While at the beginning of the COVID-19 pandemic the need for intensive care is increasing, the specific care needs of patients are still largely unknown. This is a challenge for the work of intensive care staff.

Aim: The aim of the study is to understand how intensive care nurses perceive their working conditions and the consequences for patient care.

Broad application and optimization of a single wash-step for integrated endotoxin depletion during protein purification.

Endotoxins contaminate proteins that are produced in E. coli. High levels of endotoxins can influence cellular assays and cause severe adverse effects when administered to humans.

Proof of concept study with an HER-2 mimotope anticancer vaccine deduced from a novel AAV-mimotope library platform.

Background: Anticancer vaccines could represent a valuable complementary strategy to established therapies, especially in settings of early stage and minimal residual disease. HER-2 is an important target for immunotherapy and addressed by the monoclonal antibody trastuzumab. We have previously generated HER-2 mimotope peptides from phage display libraries.

Polarity Protein Scrib Facilitates Endothelial Inflammatory Signaling.

Objective: The polarity protein Scrib is highly expressed in endothelial cells and is required for planar cell polarity. Scrib also facilitates recycling of integrin α5 to the plasma membrane. Because integrin α5 signals the presence of the inflammatory matrix protein fibronectin, we hypothesized that Scrib contributes to endothelial inflammatory signaling.

Reprogramming of myeloid angiogenic cells by Bartonella henselae leads to microenvironmental regulation of pathological angiogenesis.

The contribution of myeloid cells to tumour microenvironments is a decisive factor in cancer progression. Tumour-associated macrophages (TAMs) mediate tumour invasion and angiogenesis through matrix remodelling, immune modulation and release of pro-angiogenic cytokines. Nothing is known about how pathogenic bacteria affect myeloid cells in these processes.