Self-forced stabilization of inter-modal oscillation in multi-section semiconductor lasers at X-band.

Forced oscillation based on self-injection locked phase-locked (SILPLL) opto-electronic oscillator (OEO) technique is the basis of highly stable and low phase noise oscillators to be used as a key component in modern communication and sensing systems. To avoid large-size modular OEO, inter-modal oscillation at X-band frequencies is achieved in a compact multi-mode multi-section semiconductor laser using InP foundry service. Self-forced oscillation technique of SILPLL is demonstrated, where a phase noise performance of -98 dBc/Hz is measured at 10 kHz offset carrier of 11 GHz, which is an improvement of 68 dB compared with the free-running condition, which corresponds with 600 times reduction in calculated timing jitters from the free-running case to reach 0.

Index Finger Muscle Fatigue and Pistol Firing Failure.

Objective: The aim of this study was to analyze finger strength and effects of muscle fatigue on the ability to shoot.

Background: The finger and hand muscles of soldiers are subject to high loads. For example, the trigger pull of military pistols can amount up to 58 N (≈6 kg) and could cause muscle fatigue in the trigger finger.

Metformin-induced glucagon-like peptide-1 secretion contributes to the actions of metformin in type 2 diabetes.

Background: Metformin reduces plasma glucose and has been shown to increase glucagon-like peptide 1 (GLP-1) secretion. Whether this is a direct action of metformin on GLP-1 release, and whether some of the glucose-lowering effect of metformin occurs due to GLP-1 release, is unknown. The current study investigated metformin-induced GLP-1 secretion and its contribution to the overall glucose-lowering effect of metformin and underlying mechanisms in patients with type 2 diabetes.

Single-Dose Metformin Enhances Bile Acid-Induced Glucagon-Like Peptide-1 Secretion in Patients With Type 2 Diabetes.

Context: Despite a position as the first-line pharmacotherapy in type 2 diabetes, the glucose-lowering mechanisms of metformin remain to be fully clarified. Gut-derived modes of action, including suppression of bile acid reabsorption and a resulting increase in glucagon-like peptide-1 (GLP-1) secretion, have been proposed.

Objective: The aim of this study was to assess the GLP-1 secretory and glucometabolic effects of endogenously released bile, with and without concomitant single-dose administration of metformin in patients with type 2 diabetes.

The bile acid-sequestering resin sevelamer eliminates the acute GLP-1 stimulatory effect of endogenously released bile acids in patients with type 2 diabetes.

Aims: Discovery of the specific bile acid receptors farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) in enteroendocrine L cells has prompted research focusing on the impact of bile acids on glucagon-like peptide-1 (GLP-1) secretion and glucose metabolism. The aim of the present study was to assess the GLP-1 secretory and gluco-metabolic effects of endogenously released bile, with and without concomitant administration of the bile acid-sequestering resin, sevelamer, in patients with type 2 diabetes.

Materials And Methods: We performed a randomized, placebo-controlled, double-blinded cross-over study including 15 metformin-treated patients with type 2 diabetes.