Publications by authors named "U Riserus"
Article Synopsis
- The study explored how levels of omega-3 and omega-6 polyunsaturated fatty acids (PUFA) in the blood affect the risk of developing allergic diseases, like rhinitis, from childhood through young adulthood.
- The research involved 933 participants from the BAMSE cohort, analyzing PUFA levels at ages 8 and 16, and assessing their association with allergic reactions by age 24.
- Findings indicated that higher levels of certain PUFA, particularly omega-3 and arachidonic acid, at age 8 were linked to lower risks of rhinitis and allergic sensitization; however, these relationships might be influenced by pre-existing conditions in childhood rather than new cases that develop later.
Current cardiometabolic disease prevention guidelines recommend increasing dietary unsaturated fat intake while reducing saturated fats. Here we use lipidomics data from a randomized controlled dietary intervention trial to construct a multilipid score (MLS), summarizing the effects of replacing saturated fat with unsaturated fat on 45 lipid metabolite concentrations. In the EPIC-Potsdam cohort, a difference in the MLS, reflecting better dietary fat quality, was associated with a significant reduction in the incidence of cardiovascular disease (-32%; 95% confidence interval (95% CI): -21% to -42%) and type 2 diabetes (-26%; 95% CI: -15% to -35%).
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