Publications by authors named "U Reuning"
Background: The treatment of oral squamous cell carcinoma (OSCC) remains challenging and survival rates have not been improved significantly over the past decades. Integrins have been recognized driving the cancer progression and high expression levels cause poor outcomes in patients afflicted with OSCC. Integrin αvβ6 and its subunit integrin beta 6 (ITGB6) were discovered to enhance the invasiveness by providing beneficial effects on downstream pathways promoting the cancer progression.
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- Some patients with a tough type of head and neck cancer called HPV-negative HNSCC still don’t get better, even with better treatments.
- Scientists studied a protein called CHD4, which seems to help these cancers resist radiation therapy, making it harder to treat them.
- They found that patients with high levels of CHD4 have worse survival rates and that reducing CHD4 in lab-grown cancer cells made them more sensitive to radiation, meaning CHD4 could be a key target for future treatments.
Article Synopsis
- Triple-negative breast cancer (TNBC) is a severe and aggressive type of breast cancer with limited treatment options and poor outcomes for patients.
- The study examines the role of two proteins from the kallikrein-related peptidase (KLK) family, KLK10 and KLK11, which are found to have elevated levels in TNBC compared to other breast cancer subtypes and normal tissue.
- Higher expressions of KLK10 and KLK11 are associated with worse prognoses for TNBC patients, suggesting they could be important biomarkers and potential therapeutic targets for this challenging subtype of breast cancer.
Background: The small GTP-binding protein Rab31 plays an important role in the modulation of tumor biological-relevant processes, including cell proliferation, adhesion, and invasion. As an underlying mechanism, Rab31 is presumed to act as a molecular switch between a more proliferative and an invasive phenotype. This prompted us to analyze whether Rab31 overexpression in breast cancer cells affects expression of genes involved in epithelial-to-mesenchymal transition (EMT)-like processes when compared to Rab31 low-expressing cells.
View Article and Find Full Text PDFIntegrins have been extensively investigated as therapeutic targets over the last decades, which has been inspired by their multiple functions in cancer progression, metastasis, and angiogenesis as well as a continuously expanding number of other diseases, e.g., sepsis, fibrosis, and viral infections, possibly also Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2).
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