Publications by authors named "U Radhakrishna"
Background: Lewy body diseases, including dementia with Lewy bodies (DLB), are characterized by α-synuclein accumulation, leading to dementia. Previous studies suggest distinct epigenetic and metabolomic profiles in DLB.
Objective: This study aims to identify diagnostic biomarkers by analyzing the methylome and metabolome in the Brodmann area 7 of postmortem brain tissues from DLB patients and control subjects using multiomics approaches.
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that affects hair follicles in areas with apocrine sweat glands, such as the underarms, groin, and buttocks. The pathogenesis of HS is not fully understood, but considering the key role played by the biological clock in the control of immune/inflammatory processes the derangement of circadian and ultradian pathways could be hypothesized.
Methods: We analyzed genome-wide DNA methylation patterns in peripheral blood from 24 HS cases and 24 controls using the Infinium HumanMethylation450 BeadChip array (Illumina), followed by bioinformatics and statistical analyses.
Article Synopsis
- * In cancer, disruptions in this pathway contribute to tumor growth and the spread of cancer to other parts of the body (metastasis).
- * Understanding the core components of this pathway can aid in developing new cancer therapies and targets for treatment, especially in metastatic cases.
Introduction: Hidradenitis suppurativa (HS) is a prevalent and persistent inflammatory skin disorder, lacking a known cure or effective biomarkers for early diagnosis at present. The genetic determinants of HS have not been fully documented, but it is believed to result from a combination of genetic and environmental factors.
Methods: To identify relevant HS gene variants in sporadic HS patients, this study utilized longitudinal electronic health records (EHRs) and whole-exome sequencing.
Article Synopsis
- Neonatal Opioid Withdrawal Syndrome (NOWS) occurs when infants are exposed to opioids in utero, leading to symptoms like irritability and feeding issues, and can result in long-term health problems and increased mortality.
- A study assessed DNA methylation of drug transporter genes in placental samples from mothers with varying levels of opioid exposure, revealing significant methylation changes in both solute carrier (SLC) and ATP-binding cassette (ABC) transporters, alongside protein kinase C (PKC) genes.
- Findings suggest that these epigenetic changes could help explain drug resistance and improve treatment outcomes for infants suffering from NOWS.