[Hairy cell leukemia in pregnancy].

Pregnancy complicated by HCL is an extremlely rare event: only 5 report of HCL in pregnancy have been previously described. A 36-year-old women was diagnosed of HCL presented in 14 week of her 5th pregnancy. Therapy was initiated in 18 wk of gestation with IFN-alpha at dose 6 x 106 U subcutaneous 3 times per week and prednisone 20 mg/d.

B cells CD19+ in patients with B-cell chronic lymphocytic leukaemia and autoimmune haemolytic anaemia.

The study presents results of B and T lymphocytes population analysis in patients with chronic lymphocytic leukaemia B cells and autoimmune haemolytic anaemia (CLL-B + AIHA). We evaluated the following groups of patients: (1) with newly recognized CLL-B and co-existent AIHA (untreated), (2) after short-term treatment with corticosteroids, (3) after treatment with chemotherapy and corticosteroids. The control groups were made of patients with CLL-B without AIHA.

[Toxic effects of dichlorvos on neutrophils of human peripheral blood in vitro].

The purpose of the study was to assess the phagocytic activity and bactericidal function of human peripheral blood neutrophils exposed to dichlorvos (DDVP) an organic phosphorus pesticide in vitro. It was found that the values of the phagocytosis index in neutrophil cultures incubated with DDVP in doses of 70 microM and 100 microM increased with increasing pesticide concentration and depended on incubation duration (1 h and 2 h). The proportion of non-phagocytizing neutrophils remained at a level similar to that in controls.

Vitamin E protects human leucocytes against toxic effects of lindan in vitro.

Vitamin E (15 micrograms/ml and 60 micrograms/ml) was used for protection of human leucocytes against toxic effects of lindan (150 microM and 200 microM) in vitro. The protective effect of vitamin E manifested itself as maintenance of the phagocytic activity of granulocytes, the value of nucleologram in lymphocytes, and the proportion of euchrysin-negative lymphocytes near the values in controls.

[Protection of human peripheral blood leukocytes with vitamin E and C from toxic effects of fenarimol in vitro].

The work was undertaken in a trial to protect leukocytes against the toxic effect of fenarimol with vitamin E and C. The experiment was carried out in vitro. These vitamins were chosen since they are the components of the physiological antioxidative mechanism in the cell.