Hypertension in headache patients? A clinical study.

Objectives: The aim of the present study was to assess the prevalence of hypertension in patients with headache, coming to the observation of an Headache Center.

Materials And Methods: A total of 1486 consecutive outpatients were examined, and blood pressure was determined in all patients.

Results: Migraine without aura (MO) was the most common diagnosis, followed by migraine associated with tension-type headache, migraine with aura (MA), episodic tension-type headache (ETTH), chronic tension-type headache (CTTH), cluster headache (CH), and medication-overuse headache (MOH).

Prophylactic activity of increasing doses of intravenous histamine in refractory migraine: Retrospective observations of a series of patients with migraine without aura.

Background: Histamine is thought to play a pivotal role in the modulation of peripheral and central pain. The administration of increasing doses of histamine may lead to desensitization of receptors of histamine types 1 and 2, causing meningeal vasodilation, and to depletion of neuropeptides in the trigeminal ganglion, thus inhibiting the initiation of migraine.

Objective: In this study, the efficacy and tolerability of increasing doses of IV histamine in migraine prophylaxis were investigated.

Pupillocynetic activity of substance P in systemic sclerosis.

Objective: In systemic sclerosis (SSc), dysfunctions of peripheral nervous system (PNS) have been observed. Substance P (SP) instillation in human eye induces a cholinergic-independent pupil myosis. Pupil basal diameters (PBD) and pupil responsiveness to SP, expressed as area under the curve (AUC), were studied by pupillometry to assess SP-ergic fiber state and function in SSc.