Publications by authors named "U Nyman"
Article Synopsis
- The study aimed to enhance the Lund-Malmö GFR equation using rescaled cystatin C (r-LMR) and validate it against measured GFR in a large cohort of children and adults.
- Validation results showed that r-LMR performed with 86.2% accuracy in adults, outpacing the CAPA equation, indicating r-LMR is a reliable method for estimating GFR.
- The findings suggest that adapting the Lund-Malmö equation for rescaled cystatin C yields similar results to those based on rescaled creatinine, hinting at a reduced future need for specific GFR estimating equations.
Background: In 2015, a selective decrease in the glomerular filtration of middle-sized molecules such as cystatin C compared to small molecules such as creatinine was first described and tentatively termed "Shrunken pore syndrome." Numerous studies have thereafter found an association between this syndrome (defined by a low eGFR to eGFR ratio) and mortality and morbidity. In 2023, the syndrome was renamed selective glomerular hypofiltration syndromes (SGHS) as shrunken pores are not the only pathophysiological mechanism.
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- The study evaluates the effectiveness of machine learning (ML) techniques in predicting glomerular filtration rate (GFR) compared to the traditional EKFC equation, which measures kidney function.
- Using data from 19,629 patients across 13 cohorts, the researchers tested various ML methods, particularly focusing on factors like age, sex, and serum creatinine levels.
- Results indicated that the random forest (RF) method performed similarly to EKFC, with slight advantages for RF in younger patients, suggesting ML could enhance future GFR prediction methods.
Article Synopsis
- Exposure to iodine contrast medium (ICM) may lead to thyroid dysfunction due to excess iodide, but past studies have yielded mixed results due to their observational nature.
- A study involving 422 individuals aged 50-65 assessed thyroid hormone levels before and after contrast-enhanced CT angiography, finding a small significant effect on hormone levels but no cases of severe thyroid problems.
- The study concluded that in iodine-sufficient countries, ICM-related thyroid dysfunction is uncommon, typically mild, self-limiting, and often asymptomatic in the studied age group.
Background: Creatinine-based equations are the most used to estimate glomerular filtration rate (eGFR). The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), the re-expressed Lund-Malmö Revised (r-LMR) and the European Kidney Function Consortium (EKFC) equations are the most validated. The EKFC and r-LMR equations have been suggested to have better performances in young adults, but this is debated.
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