Publications by authors named "U Naumann"
Article Synopsis
- * The study introduces enhanced modeling techniques for neutrino flux and detector response, and it distinguishes between starting (inside) and throughgoing (outside) neutrino interaction events to improve energy resolution.
- * The findings indicate a best-fit point for the 3+1 model with sin²(2θ_{24})=0.16 and Δm_{41}²=3.5 eV², supporting previous studies while showing consistency with no evidence of sterile neutrinos, as reflected
Real-world data on the management of patients with primary biliary cholangitis (PBC) are so far scarce in Germany. Therefore, we aimed to establish a nationwide registry and describe the clinical characteristics and therapy of PBC patients.Three different cohorts defined as ursodeoxycholic acid (UDCA) responders, as inadequate responders according to Paris II criteria, and as newly diagnosed patients were prospectively recruited.
View Article and Find Full Text PDFIntroduction: This study aimed to assess the effects of a monoclonal antibody (mAb) combination on symptoms, daily function, and overall health-related quality of life.
Methods: We analyzed patient-reported outcomes data from symptomatic outpatients in a phase 1/2/3 trial. Patients with confirmed SARS-CoV-2 infection and ≥ 1 risk factor for severe COVID-19 received mAb treatment (casirivimab plus imdevimab 1200 mg) or placebo.
K channel targeting impairs DNA repair and invasiveness of patient-derived glioblastoma stem cells in culture and orthotopic mouse xenografts which only in part is predictable by K expression levels.
Int J Cancer
November 2024
Prognosis of glioblastoma patients is still poor despite multimodal therapy. The highly brain-infiltrating growth in concert with a pronounced therapy resistance particularly of mesenchymal glioblastoma stem-like cells (GSCs) has been proposed to contribute to therapy failure. Recently, we have shown that a mesenchymal-to-proneural mRNA signature of patient derived GSC-enriched (pGSC) cultures associates with in vitro radioresistance and gel invasion.
View Article and Find Full Text PDFArticle Synopsis
- - The study presents a measurement of astrophysical tau neutrinos using 9.7 years of data from the IceCube observatory, identifying seven candidate events with energies between 20 TeV and 1 PeV.
- - Convolutional neural networks were used to analyze simulated event images, helping to estimate the parent tau neutrino energy to be around 200 TeV while facing a background of about 0.5 events primarily from non-tau astrophysical neutrinos.
- - The results confirmed the presence of astrophysical tau neutrinos at a 5σ significance level, aligning with existing IceCube measurements and theoretical predictions regarding neutrino flux and oscillations.