Publications by authors named "U Morandi"
Lung cancer is the leading cancer in the world, accounting for 1.2 million of new cases annually, being responsible for 17.8% of all cancer deaths.
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- Cancer stem cells (CSCs) have been linked to chemotherapy resistance and influence disease-free survival in lung cancer patients, with a study examining their frequency and recurrence-related gene (RG) expression as potential predictors.
- An analysis of tumor specimens from 22 patients showed that both CSC frequency and RG expression were independent predictors of disease-free survival, particularly in locally advanced-stage patients.
- The study suggests that targeting CSCs and RG could improve treatment strategies and prognostic assessments for lung cancer.
Purpose: Lung cancer relapse may be associated with the presence of a small population of cancer stem cells (CSCs) with unlimited proliferative potential. Our study assessed the relationship between CSCs and the relapse rate in patients harboring adenocarcinoma (ADL) and squamous cell carcinoma of the lung (SCCL).
Experimental Design: This is an observational prospective cohort study (NCT04634630) assessing the influence of CSC frequency on relapse rate after major lung resection in 35 patients harboring early (I-II) (n = 21) and locally advanced (IIIA) (n = 14) ADL and SCCL.
Emerging evidence suggests that a small subpopulation of cancer stem cells (CSCs) is responsible for initiation, progression, and metastasis cascade in tumors. CSCs share characteristics with normal stem cells, i.e.
View Article and Find Full Text PDFA case of cervico-mediastinal paraganglioma mimicking an ectopic goiter.
Int J Surg Case Rep
September 2021
Introduction And Importance: Mediastinal paragangliomas are rare neuroendocrine tumors that originate from extra-adrenal paraganglia, occasionally secreting catecholamines. Nonfunctional mediastinal paragangliomas present nonspecific clinical and radiological features and represent a diagnostic challenge.
Case Presentation: A 53-year old woman presented with cough and dyspnea increasing over time.