Publications by authors named "U Moens"
Knowledge of Human Polyomavirus (HPyV) infection in the anal area and its association with sexually transmitted infections such as Human Papillomavirus (HPV) and Human Immunodeficiency Virus (HIV) remains limited. Therefore, anal specimens from 150 individuals of both sexes were analyzed for screening purposes. HPV DNA was found in 50.
View Article and Find Full Text PDFDespite recent advances in prevention, detection and treatment, oral squamous cell carcinoma (OSCC) remains a global health concern, strongly associated with environmental and lifestyle risk factors and infection with oncogenic viruses. Merkel Cell Polyomavirus (MCPyV), well known to be the causative agent of Merkel Cell Carcinoma (MCC) has been found in OSCC, suggesting its potential role as a co-factor in the development of oral cavity cancers. To improve our understanding about MCPyV in oral cavities, the detection and analysis of MCPyV DNA, transcripts and miRNA were performed on OSCCs and oral potentially malignant disorders (OPMDs).
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- Modified vaccinia virus Ankara (MVA) has been studied as a vaccine vector against various diseases, but concerns exist about its ability to recombine with natural viruses, potentially creating new, unpredictable viruses.
- Previous experiments showed that co-infection and superinfection of MVA with a feline cowpox virus led to the production of recombinant viruses with altered genomes and unique plaque characteristics.
- The study found that some recombinant viruses not only had a genetic composition similar to MVA-HANP but also regained lost genes and acquired new characteristics, raising safety concerns for the use of MVA in vaccines.
A comprehensive review of monkeypox virus and mpox characteristics.
Front Cell Infect Microbiol
March 2024
Monkeypox virus (MPXV) is the etiological agent of monkeypox (mpox), a zoonotic disease. MPXV is endemic in the forested regions of West and Central Africa, but the virus has recently spread globally, causing outbreaks in multiple non-endemic countries. In this paper, we review the characteristics of the virus, including its ecology, genomics, infection biology, and evolution.
View Article and Find Full Text PDFBackground: JC polyomavirus (JCPyV) persists asymptomatic in more than half of the human population. Immunocompromising conditions may cause reactivation and acquisition of neurotropic rearrangements in the viral genome, especially in the non-coding control region (NCCR). Such rearranged JCPyV strains are strongly associated with the development of progressive multifocal leukoencephalopathy (PML).
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