Diagnosis, treatment, management and monitoring of patients with tyrosinaemia type 1: Consensus group recommendations from the German-speaking countries.

Hepatorenal tyrosinaemia (HT1) is an autosomal recessive disorder of tyrosine degradation resulting in hepatic and renal dysfunction, neurological sequelae may occur in some patients. The use of nitisinone (NTBC) has revolutionised treatment and outcome of this disorder. NTBC has to be combined with a low protein diet.

Ruminal Crude Protein Degradation Determined in Sacco and by Co-Incubation of Protease and Carbohydrases.

The objectives of the study were to examine the effect of an antibiotic solution applied in the protease method (SGPM) and the effect of carbohydrases in SGPM on the effective crude protein (CP) degradation (ED) with reference to in sacco ED. For this purpose, the ruminal CP degradation of rapeseed meal, dried distillers' grains with solubles, wheat grain, corn grain, corn silage, grass silage and partial crop field pea silage was determined in sacco using three rumen-fistulated dairy cows and in vitro using SGPM. The impact of the antibiotic solution on CP degradation by protease was investigated by supplementing SGPM with Penicillin-Streptomycin solution to reduce microbial mass proliferation during incubation.

Bridging the gap between GRACE and GRACE Follow-On by combining high-low satellite-to-satellite tracking data and satellite laser ranging.

The satellite missions GRACE and GRACE Follow-On have undoubtedly been the most important sources to observe mass transport on global scales. Within the Combination Service for Time-Variable Gravity Fields (COST-G), gravity field solutions from various processing centers are being combined to improve the signal-to-noise ratio and further increase the spatial resolution. The time series of monthly gravity field solutions suffer from a data gap of about one year between the two missions GRACE and GRACE Follow-On among several smaller data gaps.

Microglia undergo molecular and functional adaptations to dark and light phases in male laboratory mice.

Microglia are increasingly recognized to contribute to brain health and disease. Preclinical studies using laboratory rodents are essential to advance our understanding of the physiological and pathophysiological roles of these cells in the central nervous system. Rodents are nocturnal animals, and they are mostly maintained in a defined light-dark cycle within animal facilities, with many laboratories investigating the molecular and functional profiles of microglia exclusively during the animals' light (sleep) phase.