Publications by authors named "U Mahadevan"
Background: Women with inflammatory bowel disease (IBD) face complexities of disease management during pregnancy and childbirth. Apprehension regarding vaginal delivery in pregnant individuals with IBD persists due to concern for perianal disease and perineal trauma. The incidence of poor wound healing after obstetric anal sphincter injury is approximately 4% in the general population.
View Article and Find Full Text PDFObjectives: Low-dose aspirin (LDA) is recommended for pregnant individuals at elevated risk for hypertensive disorders of pregnancy (HDP). However, regular aspirin use may raise concerns of increased disease activity in patients with inflammatory bowel disease (IBD). We aimed to evaluate the prevalence of LDA use in pregnant IBD patients and the effect of LDA on IBD disease activity.
View Article and Find Full Text PDFIntroduction: We aimed to compare pregnancy outcomes of women with inflammatory bowel disease using biosimilar vs originator infliximab (IFX).
Methods: In a prospective cohort of pregnant women with inflammatory bowel disease, we collected characteristics, medications, pregnancy outcomes, and developmental milestones. We compared outcomes by IFX biosimilar or originator use via bivariate statistics.
Article Synopsis
- - This study focused on developing a new imaging-based method called single-cell spatial transcriptomics (iSCST) to analyze archived, formalin-fixed, paraffin-embedded (FFPE) tissue samples from inflammatory bowel disease (IBD) patients, which helps to preserve the spatial context of various cell types within the tissue.
- - Researchers benchmarked three iSCST platforms by analyzing 57 FFPE mucosal biopsies from IBD patients and healthy controls, allowing for detailed cell analysis and gene expression profiling through a consistent data processing pipeline.
- - A custom gene panel showed the best performance for detecting and quantifying different cell subsets, revealing significant findings related to inflammation and treatment responses in ulcerative colitis, which could enhance
Background: There is no guideline regarding whether patients treated with intravenous corticosteroids for acute severe ulcerative colitis (ASUC) should be monitored in the hospital after transitioning to oral steroids. Our study aimed to: (1) compare rates of oral steroid transition failure and 30-day readmission between ASUC hospitalizations with extended inpatient monitoring compared to accelerated inpatient monitoring, and (2) identify predictors of oral steroid transition failure.
Methods: A retrospective cohort study of ulcerative colitis (UC) related admissions at UCSF from 2014 to 2022 was conducted comparing rates of steroid transition failures in extended inpatient monitoring (≥ 24 h on oral steroids prior to discharge) to accelerated inpatient monitoring (< 24 h on oral steroids).