Publications by authors named "U Madan"
Sickle cell disease (SCD) is an inherited hematologic disease caused by sickle hemoglobin as the predominant RBC hemoglobin or by sickle hemoglobin in combination with other abnormal β-hemoglobin variants like HbC, HbD and others. Sickling of erythrocytes under deoxygenated conditions is the basis of inflammatory and thrombotic cascades which result in multiple serious complications, leading to early morbidity and mortality. While HLA-matched allogeneic bone marrow transplantation is potentially curative, it has considerable limitations due to potential severe toxicities.
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- Granulomatosis with polyangiitis is a type of vasculitis affecting small to medium-sized blood vessels, with kidney involvement impacting prognosis.
- Treatment for severe cases often involves a combination of corticosteroids and medications like rituximab or cyclophosphamide, but there's no clear consensus on the best regimen.
- The case discussed highlights the effectiveness of using lower-dose cyclophosphamide alongside rituximab for patients with treatment-resistant forms of the disease and emphasizes better tolerance at lower doses.
Antimalarial Drug Artemotil Promotes Induction of Type 1 Regulatory T Cells.
Inflammation
November 2024
Artemisinin and its derivatives, used as front-line anti-malarial drugs, exhibit anti-inflammatory properties. They were found to suppress the generation and function of Th1 and Th17 cells while promoting the generation of Foxp3 + regulatory T cells (Tregs). However, the specific role of Artemotil (β-arteether) in modulating the generation and functions of CD4 + T cells, particularly Type 1 regulatory T cells (Tr1), remains to be explored.
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