Publications by authors named "U M M Bauer"
Radiation exposure during cardiac interventions in CHD: German Registry 2012-2020.
Thorac Cardiovasc Surg
January 2025
Background: Since patients with congenital heart defects (CHD) frequently require life-long medical care and repeat invasive treatment, radiation exposure during interventional procedures is a relevant issue concerning potential radiation related risks. Therefore, an analysis on radiation data from the German Registry for Cardiac Operations and Interventions in patients with CHD was performed.
Methods: From January 2012 until December 2020 a total of 28,374 cardiac catheter interventions were recorded.
Background: Patients with congenital heart defects (CHDs) are at higher risk for infectious diseases. This may partly be due to frequent hospital stays and the associated exposure to pathogens. This study aims to provide a comprehensive overview of immunisation coverage among twins in which at least one twin has CHD.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on improving the understanding and identification of molecular glue substrates related to the E3 ligase receptor cereblon (CRBN), commonly used in clinical degraders.* -
- Researchers engineered human CRBN constructs for efficient production in E. coli, achieving a balance between high binding activity and production ease.* -
- The team developed an "Enamine focused IMiD library" for high-throughput screening, successfully identifying effective binders and laying the groundwork for future CRBN glue discoveries.*
Article Synopsis
- Infants with congenital heart defects (CHDs) often face malnutrition and poor weight gain, but information on older children with CHDs is scarce.
- A nationwide online survey in Germany surveyed school-aged children (6-17 years) registered in the National Register for CHDs to evaluate their nutritional status and dietary habits.
- Results showed that children with CHDs consumed less sugary and fast food, had lower body mass index (BMI) percentiles than healthy peers, and experienced undernutrition primarily due to the severity of their CHDs and prior surgeries rather than unhealthy eating habits.
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers and several studies demonstrate that STAT3 has critical roles throughout the course of PDAC pathogenesis.
Methods: TCGA, microarray, and immunohistochemistry data from a PDAC cohort were used for clinical analyses. Panc89 cells with ADAM8 knockout, re-expression of ADAM8 mutants, and Panc1 cells overexpressing ADAM8 were generated.