Studies on the effect of antidiabetic drugs on collagen in rats.

To assess the effects of antidiabetic drugs on collagen, the study has been carried out. However, at present, no conclusive data available on the In vivo effect of antidiabetic drugs in collagen. It was therefore thought worthwhile to undertake a systemic study on the metabolic turnover of connective tissue proteins, particularly collagen which will help to understand the various changes taking place in conventional antidiabetic drug treated rats.

Preliminary toxicological report of metformin hydrochloride loaded polymeric nanoparticles.

Nanosized materials have tremendous application in every field of human activity, with a lot of economic benefit increasing nanoparticle research and use. There are number of nanosized products already available commercially and many others are in queue. Therefore, there is a pressing need for careful consideration of benefits and side effects of the use of nanoparticles in medicine.

Sub acute toxicity assessment of glipizide engineered polymeric nanoparticles.

To our knowledge, no such polymeric nanoparticle formulation toxicity study has been reported for oral use. The oral route of drug administration is generally preferred because of its versatility, safety and relative patient comfort. Hence, there is an outstanding need of research for polymeric nanoparticles to find whether they are stable for prolonged shelf life, and yet have no toxicity when administered orally.