Publications by authors named "U Lei"
Article Synopsis
- Palmoplantar keratoderma is a complex skin condition with diverse clinical presentations and genetic factors, making diagnosis challenging and sparking the need for comprehensive genetic testing.
- This study collected data from 142 patients over several years to understand the different types and genetic causes of palmoplantar keratoderma by examining clinical features and performing genetic sequencing.
- Results revealed that a significant proportion (83%) of families had identifiable genetic variants, with the most common variant linked to the AAGAB gene, affecting the majority of participants who presented with a punctate subtype of the condition.
Article Synopsis
- Ectodermal dysplasias are rare genetic disorders characterized by features like missing teeth (hypodontia), hair loss (hypotrichosis), and impaired sweating (hypohidrosis), with limited research on their prevalence in the general population.
- This study aimed to create a reliable population-based cohort of ectodermal dysplasia patients in Denmark, assessing prevalence and their characteristics using comprehensive health registry data from 1995 to 2021.
- The research identified 396 patients, establishing a minimum birth prevalence of 14.5 cases per 100,000 live births and confirming that a majority of diagnosed cases were correctly coded in health registries.
Background And Objectives: Solid organ transplant recipients (SOTRs) are at increased risk of skin cancer and suffer from greater disease-specific morbidity and mortality. To risk stratify the expanding SOTR population for more targeted skin cancer screening, a detailed understanding of risk factors is needed. Using combined clinical and pathological data to capture prevalence of actinic keratosis (AK) and skin cancer, this study aimed to identify risk factors of skin cancer development in a Danish SOTR cohort.
View Article and Find Full Text PDFCommunity-Based Testing for SARS-CoV-2 - Chicago, Illinois, May-November 2020.
MMWR Morb Mortal Wkly Rep
May 2021
On May 13, 2020, Chicago established a free community-based testing (CBT) initiative for SARS-CoV-2, the virus that causes COVID-19, using reverse transcription-polymerase chain reaction (RT-PCR). The initiative focused on demographic groups and geographic areas that were underrepresented in testing by clinical providers and had experienced high COVID-19 incidence, including Hispanic persons and those who have been economically marginalized. To assess the CBT initiative, the Chicago Department of Public Health (CDPH) compared demographic characteristics, economic marginalization, and test positivity between persons tested at CBT sites and persons tested in all other testing settings in Chicago.
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