Publications by authors named "U Laufs"
Aims: Atrial fibrillation (AF) accounts for about 20% of all ischemic strokes worldwide. It is known that AF impairs health-related quality of life (HRQOL) in the general population, but data on HRQOL in stroke patients with newly diagnosed AF are sparse.
Methods: Post hoc analysis of the prospective, investigator-initiated, multicenter MonDAFIS study (NCT02204267) to analyze whether AF-related oral anticoagulation (OAC), and/or AF-symptom severity are associated with HRQOL after ischemic stroke or transient ischemic attack (TIA).
Background: The timing of coronary angiography in patients with successfully resuscitated out-of-hospital cardiac arrest and missing ST-segment elevations on the electrocardiogram has been investigated in 2 large randomized controlled trials, TOMAHAWK (Angiography After Out-of-Hospital Cardiac Arrest Without ST-Segment Elevation) and COACT (Coronary Angiography After Cardiac Arrest Trial). Both trials found neutral results for immediate vs delayed/selective coronary angiography on short-term all-cause mortality. The TOMAHAWK trial showed a tendency towards harm with immediate coronary angiography, though not statistically significant with traditional frequentist methods.
View Article and Find Full Text PDFArticle Synopsis
- - Sacubitril/valsartan significantly improves outcomes in patients with chronic heart failure and reduced ejection fraction, enhancing left ventricular (LV) function over six months of treatment.
- - Key improvements were observed, including increased LV contractility (Ees), decreased afterload (Ea), and enhanced ventricular-arterial coupling ratio (Ea/Ees), along with a notable increase in left ventricular ejection fraction (LVEF) from 33% to 43%.
- - The study found positive correlations between changes in LVEF and LV contractility, as well as between NT-proBNP levels and left ventricular end-diastolic pressure (LVEDP), suggesting these factors play a role in the treatment's effectiveness
Aims: Exercise-induced cellular stress and sterile inflammation are of increasing interest. ASC specks are a component of the intracellular NLRP3-inflammasome and can be released into the blood. For example, serum ASC specks are increased after marathon running.
View Article and Find Full Text PDFBackground: Hypertrophic cardiomyopathy (HCM) with or without left ventricular outflow tract (LVOT) obstruction is a common primary myocardial disease, with a prevalence of 1:500. It is characterized by thickening of the myocardium. Its diagnostic evaluation includes history-taking and physical examination, genetic studies, transthoracic echocardiography, and cardiac MRI.
View Article and Find Full Text PDF