Publications by authors named "U Kroening"
[Photometry of Mycobacteria and its application in sensitivity-testing of chemotherapeutic agents (author's transl)].
Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol
March 1982
Article Synopsis
- The study utilized photometry to measure mycobacterial growth in a modified 7H9 medium, achieving a significant increase in extinction values within 8 days.
- Experiments were conducted at different pH levels (5.5, 6.8, and 7.3) to evaluate how pH affected the growth of various mycobacterial strains and the inhibitory power of antituberculous drugs.
- The photometric method demonstrated a quicker sensitivity testing process compared to conventional methods, with results aligning well between the two techniques, showcasing advantages for certain drugs like Pyrazinamide and Tetracycline.
The antibiotic concentrations were determined in 28 serum samples, 24 samples of lung parenchyma and 21 samples of the skeletal muscle from 28 patients who had undergone pneumonectomy. 5 g mezlocillin had been given i. v.
View Article and Find Full Text PDF[Concentration of cefamandole in human renal parenchyma (author's transl)].
Arzneimittelforschung
February 1982
(6R-[6alpha,7beta(R)])-7-[(hydroxyphenylacetyl)amino]-3-([(1-methyl-1H-tetrazol-5-yl)-thio]methyl)-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carbonic acid (cefamandole) levels have been determined in human renal tissue, serum, and urine of 17 patients undergoing therapeutic nephrectomies after 3 i.v. applications of 2 g cefamandole.
View Article and Find Full Text PDFInvestigation of kidneys from 20 patients revealed relatively low tobramycin concentrations in cortex and medulla after one day of treatment. After administration for several days a significant accumulation was observed in only one of three patients. Attention is drawn to the higher tobramycin concentrations found in renal parenchyma which has undergone chronic inflammatory changes compared to the "normal" values in kidneys infiltrated by tumours.
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