Publications by authors named "U Klaasen"
J Clin Oncol
February 1998
Article Synopsis
- The study aimed to evaluate the effectiveness of high-dose infusional fluorouracil (FU) when combined with leucovorin (LV), interferon (IFN) alpha-2b, or both in patients with metastatic colorectal cancer.
- Patients (n = 236) were randomized into three groups to receive FU24h with either LV, IFN, or a combination, assessing response rates, time to tumor progression (TTP), and overall survival.
- Results showed that FU24h/LV had a significantly higher remission rate and longer TTP and survival compared to FU24h/IFN, while the addition of IFN did not improve outcomes and increased toxicity, suggesting FU24h/LV is the more promising treatment
