Publications by authors named "U Kintscher"
Objectives: Home blood pressure monitoring (HBPM) is valuable for the detection and monitoring of hypertension. Despite logistical advantages, HBPM has not yet been used in national blood pressure (BP) surveys. We investigated randomly selected adults' willingness to participate in an HBPM study (attitude survey) and piloted this approach (feasibility study).
View Article and Find Full Text PDFNeurodegenerative diseases typically emerge after an extended prodromal period, underscoring the critical importance of initiating interventions during the early stages of brain aging to enhance later resilience. Changes in presynaptic active zone proteins ("PreScale") are considered a dynamic, resilience-enhancing form of plasticity in the process of early, still reversible aging of the Drosophila brain. Aging, however, triggers significant changes not only of synapses but also mitochondria.
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- Anthracyclines, like Doxorubicin, are powerful anti-cancer drugs but can cause serious heart damage known as anthracycline-induced cardiotoxicity (AIC).
- A study using mice showed that AIC leads to systolic dysfunction and changes in the structure of the heart's left ventricle, with specific alterations in diffusion properties detectable by magnetic resonance imaging.
- The findings suggest that diffusion tensor imaging (DTI) could help in diagnosing and understanding the heart issues caused by AIC, calling for more research in clinical settings.
Aims: Heart failure with preserved ejection fraction (HFpEF) is a multifactorial, multisystemic syndrome that involves alterations in lipid metabolism. This study aimed to test whether distinct plasma lipid profiles or lipid entities or both are associated with clinical and functional echocardiographic parameters in HFpEF.
Methods And Results: We examined the human plasma lipidome in HFpEF patients (n = 18) with left ventricular ejection fraction ≥50% and N-terminal pro-brain natriuretic peptide (NT-proBNP) >125 pg/mL and control subjects (n = 12) using mass spectrometry-based shotgun lipidomics.