Publications by authors named "U Kessler"
Effects of Electroconvulsive Therapy on Brain Structure - a Neuroradiological Investigation into White Matter Hyperintensities, Atrophy, and Microbleeds.
Biol Psychiatry Cogn Neurosci Neuroimaging
December 2024
Background: Electroconvulsive therapy (ECT) is a well-established treatment for severe depression, yet it remains stigmatized due to public perceptions linking it with brain injury. Despite extensive research, the neurobiological mechanisms underlying ECT are not fully elucidated. Recent findings suggest that ECT may work through disrupting depression circuitry.
View Article and Find Full Text PDFBackground: How cognition is influenced by electroconvulsive treatment (ECT) and major depressive disorder (MDD) is still debated. The development and etiology of neurocognitive impairment in MDD were examined by investigating the cognitive profile following ECT related to the state, scar, and trait perspectives, with the former predicting improvements parallel with depressive symptoms, while the two latter expected persisting impairments. Executive functions (EF) and attention are central to cognition and alterations in these functions could influence other domains like memory.
View Article and Find Full Text PDFThe Global ECT MRI Research Collaboration (GEMRIC) has collected clinical and neuroimaging data of patients treated with electroconvulsive therapy (ECT) from around the world. Results to date have focused on neuroimaging correlates of antidepressant response. GEMRIC sites have also collected longitudinal cognitive data.
View Article and Find Full Text PDFArticle Synopsis
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Background: Increased gray matter volume (GMV) following electroconvulsive therapy (ECT) has been well-documented, with limited studies reporting a subsequent decrease in GMV afterwards.
Objective: This study characterized the reversion pattern of GMV after ECT and its association with clinical depression outcome, using multi-site triple time-point data from the Global ECT-MRI Research Collaboration (GEMRIC).
Methods: 86 subjects from the GEMRIC database were included, and GMV in 84 regions-of-interest (ROI) was obtained from automatic segmentation of T1 MRI images at three timepoints: pre-ECT (T), within one-week post-ECT (T), and one to six months post-ECT (T).