Publications by authors named "U K Mehta"
Aspirin is used in patients with coronary artery disease essential in both acute and chronic phases of treatment, especially post-catheterization and post-coronary artery stent placement. Some patients have sensitivity to aspirin. Hypersensitivity reaction symptoms include itchy and watery eyes, itchy rash, worsening asthma, wheezing to fatal angioedema, and anaphylaxis.
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- The study compared the Roussel Uclaf Causality Assessment Method (RUCAM) with a multidisciplinary expert panel to assess drug-induced liver injury (DILI) from antituberculosis and antiretroviral therapies.
- It involved 48 participants, all of whom were people with HIV, with many on multiple potentially harmful medications, which made it challenging to identify the exact cause of liver injury.
- The results showed that the RUCAM had low sensitivity (7%) but high specificity (100%) in identifying probable or certain drug causes of liver injury, indicating it isn't very reliable in this context compared to the expert panel.
Article Synopsis
- The study investigated how COVID-19 disruptions affected neuroscience research projects and young researchers in India through an online survey targeting medical trainees, post-docs, PhD students, and early career faculty.
- A total of 504 valid responses revealed that over 83% of participants experienced negative impacts on their research, with one-third noting delays and many adapting their methodologies due to the pandemic.
- The findings highlighted significant challenges, particularly for those involved in prospective studies, emphasizing the need for focused support for neuroscience research in the post-pandemic landscape.
We aimed to assess the incremental value of schizophrenia polygenic risk score (PgRS) and resting-state functional brain connectivity (rsFC) when added to clinical data in predicting the six-week response to oral risperidone (Risperdal) in schizophrenia. Fifty-seven, 54, and 43 individuals in a group of never-before-treated first-episode schizophrenia had good quality whole-genome sequencing (10x), rsFC, and both genomic and rsFC data, respectively, at baseline. Symptom severity ratings were obtained at baseline and six-weeks of oral risperidone (Risperdal) treatment.
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