Publications by authors named "U K Allahwala"
Lipid lowering therapies for aortic stenosis: a drug-target Mendelian randomisation study.
Eur Heart J Cardiovasc Pharmacother
November 2024
Background: Traditional prognostic models for ST-segment elevation myocardial infarction (STEMI) have limitations in statistical methods and usability.
Objective: We aimed to develop a machine-learning (ML) based risk score to predict in-hospital mortality, intensive care unit (ICU) admission, and left ventricular ejection fraction less than 40% (LVEF < 40%) in STEMI patients.
Methods: We reviewed 1,863 consecutive STEMI patients undergoing primary percutaneous coronary intervention (pPCI) or rescue PCI.
Article Synopsis
- * Out of 66 ACS patients, 94% were diagnosed with OSA, with 68% having moderate-to-severe cases; however, common screening questionnaires were not effective in identifying these severe cases.
- * Although increased arterial stiffness and carotid intima-media thickness were found in patients with moderate-to-severe OSA, these findings were not statistically significant after adjusting for other factors, indicating potential limitations in the study's conclusions.
Background: The broader implications of the Coronavirus disease 2019 pandemic on cardiovascular hospitalizations remain unclear. We aimed to assess trends in cardiovascular presentations during the Coronavirus disease 2019 pandemic.
Methods: This multicentre study examined cardiovascular presentations from March 2018 to February 2023.
Coronary artery blood flow is influenced by various factors including vessel geometry, hemodynamic conditions, timing in the cardiac cycle, and rheological conditions. Multiple patterns of disturbed coronary flow may occur when blood flow separates from the laminar plane, associated with inefficient blood transit, and pathological processes modulated by the vascular endothelium in response to abnormal wall shear stress. Current simulation techniques, including computational fluid dynamics and fluid-structure interaction, can provide substantial detail on disturbed coronary flow and have advanced the contemporary understanding of the natural history of coronary disease.
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