Publications by authors named "U Gyllensten"
Understanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioural traits and the disease aetiology of neuropsychiatric disorders. Here the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,000 individuals for 184 neuro-related proteins in human plasma. The analysis identified 125 cis-regulatory protein quantitative trait loci (cis-pQTL) and 164 trans-pQTL.
View Article and Find Full Text PDFOvarian cancer is the 8th most common cancer among women and has a 5-year survival of only 30-50%. While the survival is close to 90% for stage I tumours it is only 20% for stage IV. Current biomarkers are not sensitive nor specific enough, and novel biomarkers are urgently needed.
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- * The research showed that individuals with high polygenic risk scores have significantly higher blood pressure (almost 17 mmHg more) and over seven times the risk of developing hypertension compared to those with low scores.
- * Incorporating these genetic risk scores into hypertension prediction models improved their accuracy, and excitingly, similar genetic associations were found in a large African-American sample, underscoring the potential of these findings for precision health initiatives.
Article Synopsis
- Early detection is crucial for improving survival rates in ovarian cancer, but there's no current general screening due to the absence of reliable biomarkers and cost-effectiveness issues.
- The study used self-collected dried cervico-vaginal fluid (CVF) and mass spectrometry to identify an 11-protein panel that distinguishes between cancer cases and healthy controls.
- Validation showed the panel has a high sensitivity of 0.97 and moderate specificity of 0.67, suggesting it can also indicate future cancer risk, potentially paving the way for new ovarian cancer screening methods.