Publications by authors named "U Guenther"
Article Synopsis
- Disorientation is a key early sign of postoperative delirium (POD), which can lead to serious health issues, but existing tools like CAM-ICU can't assess disorientation in intubated patients.
- Researchers developed the Confusion Assessment Method for Intermediate Care Unit (CAM-IMC) by combining CAM-ICU variables with disorientation testing to improve POD diagnosis in non-intubated patients.
- In a study of 178 patients, CAM-IMC showed high diagnostic accuracy with a sensitivity of 96% and specificity of 94%, highlighting its reliability as a tool for identifying POD in postoperative settings.
Objective: Vasoplegic syndrome remains a common complication of cardiac surgery. It has serious implications for the healthcare system and individual patients, as it leads to rising healthcare costs and higher mortality. A better understanding of factors triggering vasoplegic syndrome is essential for the development of effective prevention strategies.
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- RNA helicases are important for maintaining RNA levels in cells and are linked to diseases, such as SMARD1, which is associated with the IGHMBP2 protein.* -
- IGHMBP2 helps in translating specific mRNAs by preventing ribosome stalling, which is crucial for synthesizing proteins involved in the THO complex, important for mRNA production and export.* -
- Problems with IGHMBP2 regulation can disrupt cellular processes and may play a role in the development of SMARD1, highlighting potential targets for new treatments.*
Growth factor independence 1 (GFI1) is a transcriptional repressor protein that plays an essential role in the differentiation of myeloid and lymphoid progenitors. We and other groups have shown that GFI1 has a dose-dependent role in the initiation, progression, and prognosis of acute myeloid leukaemia (AML) patients by inducing epigenetic changes. We now demonstrate a novel role for dose-dependent GFI1 expression in regulating metabolism in haematopoietic progenitor and leukaemic cells.
View Article and Find Full Text PDFPurpose: To compare ICU-free (ICU-FD) and ventilator-free days (VFD) in the 30 days after randomization in patients that received isoflurane or propofol without receiving the other sedative.
Materials And Methods: A recent randomized controlled trial (RCT) compared inhaled isoflurane via the Sedaconda® anaesthetic conserving device (ACD) with intravenous propofol for up to 54 h (Meiser et al. 2021).