Optical coherence tomography in patients with schizophrenia: An exploratory study.

Background: Neurodegeneration plays an important role in the pathophysiology of schizophrenia. Conventional imaging has limited sensitivity in identifying early degenerative changes in the brain. Optical Coherence Tomography (OCT) is a noninvasive method for assessing retinal changes, providing a window into the central nervous system.

Association between smartphone addiction and sedentary behaviour amongst children, adolescents and young adults: A Systematic Review and meta-analysis.

Background: The rapid proliferation of smartphones has raised concerns about their impact on physical activity levels, particularly among younger demographics. While smartphones offer numerous benefits, there is growing evidence to suggest that excessive use may lead to sedentary behaviours, potentially impacting physical health adversely. Hence, this review was done to explore the association between smartphone addiction and reduced physical activity amongst children, adolescents and young adults.

Counterfactual Bidirectional Co-Attention Transformer for Integrative Histology-Genomic Cancer Risk Stratification.

Applying deep learning to predict patient prognostic survival outcomes using histological whole-slide images (WSIs) and genomic data is challenging due to the morphological and transcriptomic heterogeneity present in the tumor microenvironment. Existing deep learning-enabled methods often exhibit learning biases, primarily because the genomic knowledge used to guide directional feature extraction from WSIs may be irrelevant or incomplete. This results in a suboptimal and sometimes myopic understanding of the overall pathological landscape, potentially overlooking crucial histological insights.

KDM3A controls postnatal hippocampal neurogenesis via dual regulation of the Wnt/β-catenin signaling pathway.

Hippocampal neurogenesis, the generation of new neurons in the dentate gyrus (DG) of mammalian hippocampus, is essential for cognitive and emotional processes. Despite advances in understanding the transcription factors and signaling pathways that regulate DG neurogenesis, the epigenetic mechanisms underlying the molecular changes necessary for granule neuron generation remain poorly understood. In this study, we investigate the role of the H3K9 demethylase KDM3A in postnatal neurogenesis in mouse DG.