Publications by authors named "U Gamerdinger"
Phage display technology (PD) is a powerful technique for the generation of tumor‑targeting antibodies. However, there are a number of different selection methods established in different laboratories around the world. Cell‑based PD panning methods using primary tumor cells are particularly heterogeneous between laboratories, which can lead to inconsistent results.
View Article and Find Full Text PDFMucoepidermoid carcinoma is the most common primary salivary gland malignancy and its tumor grading has an important prognostic significance. The 5 year overall survival rate is significantly higher for low grade mucoepidermoid carcinomas than for intermediate grade and high grade mucoepidermoid carcinomas. The translocation of t(11;19)(q21;p13) with the resulting CRTC1-MAML2 transfusion appears to be of prognostic relevance in patients with mucoepidermoid carcinoma.
View Article and Find Full Text PDFArticle Synopsis
- - The study focuses on patients with HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) who experience recurrence or metastasis, aiming to identify genetic alterations linked to these poor outcomes.
- - Researchers conducted chromosomal analyses and gene sequencing, finding that patients with recurrence had higher mutation rates in key genes (like HRAS, PIK3R1, STK11, and TP63) compared to those with successful tumor control.
- - The findings suggest that specific genetic changes in HPV-driven OPSCC might account for a worse prognosis, which could inform future treatment strategies and patient management.