Publications by authors named "U Galli"
Article Synopsis
- Despite the rise of new therapeutic targets for cancer treatment, antitubulin drugs like TN-16 continue to play a vital role in cancer therapies for both adults and children.
- Researchers developed a new, efficient method to produce TN-16 and its aza-analogs, creating a library of 62 compounds, with three showing strong potency against cancer cells.
- The active compounds demonstrated their ability to induce cell cycle arrest and disrupt microtubules, leading to increased α-tubulin acetylation, although their impact on cellular tubulin polymerization was less pronounced.
Article Synopsis
- The modification of biomolecules through chemical processes is fundamental to the physiology of living organisms, but some processes, like sulfo-conjugation by sulfotransferases (SULT), are less understood, especially in insects like mosquitoes.
- This research focuses on a specific mosquito SULT enzyme (AGAP001425), revealing its unique expression patterns and potential role in the reproductive physiology of mosquitoes, indicating its importance for insect management strategies.
- Structural studies of the enzyme show significant differences compared to other SULTs, particularly in its dynamic region, which could inform the development of inhibitors to disrupt its function and help control mosquito populations.
Besides the well-known double-helical conformation, DNA is capable of folding into various noncanonical arrangements, such as G-quadruplexes (G4s) and i-motifs (iMs), whose occurrence in gene promoters, replication origins, and telomeres highlights the breadth of biological processes that they might regulate. Particularly, previous studies have reported that G4 and iM structures may play different roles in controlling gene transcription. Anyway, molecular tools able to simultaneously stabilize/destabilize those structures are still needed to shed light on what happens at the biological level.
View Article and Find Full Text PDFContrasting results exist on the association between CTLA-4 rs231775 and acute rejection in kidney transplant recipients. We herein conducted an updated systematic review with meta-analysis and trial sequential analysis (TSA) to clarify this relationship and to establish whether the current evidence is sufficient to draw firm conclusions. In addition, noteworthiness of significant pooled odds ratios (ORs) was estimated by false positive report probability (FPRP).
View Article and Find Full Text PDFIn the present study we systematically re-analyzed results from meta-analyses and genome-wide association studies (GWASs) to assess the credibility of genetic associations with acute rejection risk in renal transplantation. A comprehensive literature search was performed on PubMed, Web of Knowledge, Cochrane library, and Open Grey up to July 2019. Methodological quality of systematic meta-analyses was assessed by the AMSTAR tool.
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