Publications by authors named "U G Zachariah"
Background: The world health organization (WHO) classification of neuroendocrine neoplasms (NENs, i.e. neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs)) of the gastrointestinal system involves grading of these tumors by mitotic count (i.
View Article and Find Full Text PDFOn-treatment decline in MELD score predicts one-month transplant-free survival in rodenticidal hepatotoxicity patients treated with low-volume plasma exchange.
Indian J Gastroenterol
December 2024
Article Synopsis
- Plasma exchange (PLEX) is shown to improve survival rates in patients with rodenticidal hepatotoxicity, but the factors that predict treatment success remain unclear.
- A study analyzed 200 patients over nearly a decade to identify predictors of survival, focusing on changes in MELD score, bilirubin levels, and INR after PLEX treatment.
- Results indicated that a significant decline in MELD score during treatment was the strongest independent predictor of one-month survival without liver transplantation.
In an era of EUS-guided interventions, direct glue injection remains relevant in management algorithm for bleeding isolated gastric varices -1.
Indian J Gastroenterol
July 2024
Background: Low-volume plasma exchange (PLEX) and low-dose steroid improve survival in severe alcoholic hepatitis. We aimed to compare one-year survival of very severe alcoholic hepatitis (VSAH) patients treated with centrifugal PLEX (cPLEX), membrane PLEX (mPLEX) or standard medical treatment (SMT).
Methods: We retrospectively analyzed survival in consecutive VSAH patients treated at our department from November 2017 to September 2021.
Article Synopsis
- Therapeutic plasma exchange (PLEX) is being used more frequently as a treatment for acute liver failure (ALF), either alone or as a bridge to liver transplantation, with its effectiveness potentially varying based on the cause of liver failure.
- This systematic review and meta-analysis analyzed studies comparing PLEX with standard medical therapy, focusing on mortality rates and adverse events over 60 and 90 days.
- Findings revealed that PLEX significantly reduced mortality compared to standard treatment, especially in cases of ALF with single identifiable causes, showing no major side effects linked to the procedure.