Dysregulated NOX1-NOS2 activity as hallmark of ileitis in mice.

Inflammation of the ileum, or ileitis, is commonly caused by Crohn's disease (CD) but can also accompany ulcerative colitis (backwash ileitis), infections or drug-related damage. Oxidative tissue injury triggered by reactive oxygen species (ROS) is considered part of the ileitis etiology. However, not only elevated ROS but also permanently decreased ROS are associated with inflammatory bowel disease (IBD).

Aquaponic growth of basil (Ocimum basilicum) with African catfish (Clarias gariepinus) in standard substrate combined with a Humicacid Fiber-Substrate (HFS).

A major challenge in agriculture, horticulture and aquaponics practices is the reduction of mineral fertilisers and peat to reduce CO emissions and increase sustainability. This study used a three-phase-natural fertiliser, the Humicacid Fiber-Substrate (HFS), made from natural regenerative organic and mineral-fractions (Humus-Mineral-Complex), to reduce the peat content in plant pots for aquaponics farming. Basil (Ocimum basilicum) growth was compared with i) 100% standard media substrate ("Einheitserde", white peat 80%, clay 20%), and ii) 85% "Einheitserde" and 15% of HFS under irrigation with aquaculture process waters from an extensive and intensive production of African catfish (Clarias gariepinus) under coupled aquaponic conditions.

Case report: Neonatal-onset inflammatory bowel disease due to novel compound heterozygous mutations in .

Very Early Onset Inflammatory Bowel Disease (VEO-IBD) is potentially associated with genetic disorders of the intestinal epithelial barrier or inborn errors of immunity (IEI). Dual oxidase 2 (DUOX2), an HO-producing NADPH oxidase expressed at apical enterocyte membranes, plays a crucial role in innate defense response. Biallelic mutations have been described only in two patients with VEO-IBD to date.