Publications by authors named "U Frey"
Background: Little is known about the mediating role of nasal microbiome on the association between pre- and postnatal air pollution exposure and subsequent respiratory morbidity in infancy. We aimed to examine the impact of air pollution on microbiome and respiratory symptoms, and whether microbiome mediates the association between air pollution and symptoms.
Methods: Nasal swabs from 270 infants in the prospective Basel-Bern Infant Lung Development cohort were analyzed by 16S ribosomal RNA gene sequencing.
Asthma is a widespread respiratory disease affecting millions of children. Salbutamol is a well-established bronchodilator available to treat asthma. However, response to bronchodilators is very heterogeneous, particularly in children.
View Article and Find Full Text PDFBackground: The respiratory microbiota influences infant immune system maturation. Little is known about how perinatal, physiological, and environmental exposures impact the nasal microbiota in preterm infants after discharge, or nasal microbiota differences between preterm and healthy full-term infants.
Methods: Nasal swabs (from 136 preterm and 299 full-term infants at mean postmenstrual age of 45 weeks from the prospective Basel-Bern Infant Lung Development cohort) were analyzed by 16S-rRNA gene amplification and sequencing (Illumina MiSeq).
Background: Respiratory tract infections (RTIs) drive lung function decline in children with cystic fibrosis (CF). While the respiratory microbiota is clearly associated with RTI pathogenesis in infants without CF, data on infants with CF is scarce. We compared nasal microbiota development between infants with CF and controls and assessed associations between early-life nasal microbiota, RTIs, and antibiotic treatment in infants with CF.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates how early-life risk factors from both host and environment interact with an infant's respiratory system to influence the development of wheezing and asthma over time.
- - Researchers analyzed data from two large cohorts of healthy infants (BILD and PASTURE) to identify the effects of various factors on wheezing and asthma outcomes, specifically tracking symptom severity scores over the first year of life.
- - Findings showed a complex dynamic interplay between different risk factors and breathing symptoms, ultimately highlighting the importance of these interactions in predicting respiratory health outcomes in young children.