Publications by authors named "U Ezer"
Article Synopsis
- - This chapter discusses the rising importance of mesenchymal stromal/stem cells (MSCs) in regenerative medicine and highlights their applications in advanced therapy medicinal products (ATMPs).
- - It emphasizes advancements in cell culture technologies that enable large-scale MSC production while adhering to Good Manufacturing Practices (GMP) for safety and efficacy.
- - The text presents an optimized upstream protocol for laboratory-scale MSC production from various tissue sources, which is crucial for effective downstream processing and clinical applications.
Background: Regular coffee consumption has beneficial and preventative effects on liver and chronic neurodegenerative diseases. However, the studies performed with the ingredients found in coffee beverages have not clarified the responsible mechanisms. Exosomes are small, membrane-coated cargo packages secreted by prokaryote and eukaryote cells.
View Article and Find Full Text PDFScreening of Variations in CD22 Gene in Children with B-Precursor Acute Lymphoblastic Leukemia.
Genet Test Mol Biomarkers
September 2016
Background: CD22 is expressed on the surface of B-cell lineage cells from the early progenitor stage of pro-B cell until terminal differentiation to mature B cells. It plays a role in signal transduction and as a regulator of B-cell receptor signaling in B-cell development.
Objectives: We aimed to screen exons 9-14 of the CD22 gene, which is a mutational hot spot region in B-precursor acute lymphoblastic leukemia (pre-B ALL) patients, to find possible genetic variants that could play role in the pathogenesis of pre-B ALL in Turkish children.
This study was undertaken to determine the prevalence of the Factor V 1691 G-A and PT 20210 G-A mutations in Turkish children with leukemia. We genotyped 135 pediatric leukemia patients with for these mutations. Eleven (8%) of the 135 patients were heterozygous for the FV 1691 G-A mutation.
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