Associations of Maternal Salivary Cortisol and Psychological Symptoms With Human Milk's Microbiome Composition.

Objective: Human milk (HM) is considered the best source of infant nutrition with many benefits for the infant. However, pregnancy changes can lead to increased stress in some women, which might affect HM composition. Although studies have demonstrated a link between maternal psychopathology and child development, it remains unclear how maternal psychobiological changes can be intergenerationally transmitted.

Allopregnanolone and mood in the peripartum: a longitudinal assessment in healthy women.

Background: Allopregnanolone (ALLO), a neuroactive steroid hormone derived from progesterone, can modulate mood via the GABA-A receptor. Peripartum mood can be influenced by psychosocial factors, previous mental illness, and hormonal changes. Studies suggest a U-shaped effect of ALLO on mood, with some women being more sensitive to hormonal changes than others.

Network structure of functional somatic symptoms.

Objective: The overlap among functional somatic syndromes (FSS) is substantial, which is why various empirical attempts at an improved understanding of related symptoms have been undertaken. Network analyses are particularly valuable from a clinical point of view, since they focus on the extent to which symptoms expression is co-dependent. The aim of this study was to provide the first estimation of the network structure of symptoms in 17 FSS.

Estradiol and progesterone from pregnancy to postpartum: a longitudinal latent class analysis.

Introduction: During the peripartum, women undergo significant hormonal changes that are crucial for fetal development and a healthy pregnancy and postpartum period for mother and infant. Although several studies have determined healthy norm ranges of estradiol and progesterone, there are discrepancies among the reports, rendering it unclear which hormone levels are linked to adverse health outcomes. To account for the impact of sex steroid patterns on health outcomes in mothers and children, a longitudinal assessment of different parameters is needed.

Personality vulnerability to depression, resilience, and depressive symptoms: epigenetic markers among perinatal women.

Background: We examined differences in DNA methylation patterns in the and genes in relation to personality vulnerability to depression, resilience, and perinatal depressive symptoms, whilst also considering possible moderating effects of childhood traumatic events.

Methods: = 160 perinatal women were assessed at late pregnancy and 1 year postpartum for personality vulnerability to depression, resilience, depressive symptoms, and childhood traumatic events with self-reported questionnaires. and methylation markers were analyzed via sodium bisulfite sequencing.