Publications by authors named "U Duvvuri"
Background: Human papillomavirus (HPV) negative oropharyngeal squamous cell carcinoma (OPSCC) is associated with worse survival when compared to HPV-positive OPSCC. Primary surgery is one option to intensify therapy in this high-risk group of patients. Unfortunately, the only randomized trial to explore this approach (RTOG 1221) failed to accrue and the role of primary surgery in the treatment of HPV-negative OPSCC remains unanswered.
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- Recent findings highlight the importance of communication between lysosomes and mitochondria in regulating tumor growth, particularly in squamous cell carcinomas (SCCHN) with high TMEM16A expression.
- About 30% of SCCHN cases overexpress TMEM16A, leading to increased mitochondrial content and reliance on mitochondrial complex I for cancer cell survival.
- Targeting the interaction between lysosomal and mitochondrial functions may offer new therapeutic strategies for improving outcomes in patients with SCCHN.
Article Synopsis
- * Out of 31 patients, 55% showed a significant drop in tumor activity (major pathologic response), along with increased immune cell presence in the tumors.
- * Findings indicate that this combination therapy not only activates various immune responses but is also linked to specific genetic markers in immune cells and changes in gut microbiota, suggesting potential pathways for enhancing treatment outcomes.
Objectives: Transoral robotic surgery (TORS) for the treatment for oropharyngeal squamous cell carcinoma (SCC) carries a risk of post-operative hemorrhage. Increased time from surgery to completion of adjuvant therapy has been associated with decreased survival. Our objective was to assess for adjuvant treatments delays in patients with post-operative bleeding.
View Article and Find Full Text PDFIntroduction: Frailty is a recognized condition associated with poorer outcomes in patients with head and neck cancer (HNC). The objective of this study was to ascertain the prognostic significance of various frailty metrics on short-term treatment toxicity in patients with HNC undergoing curative-intent therapy.
Materials And Methods: A systematic review was performed searching multiple databases.