Alternative splicing controls teneurin-3 compact dimer formation for neuronal recognition.

Neuronal network formation is facilitated by recognition between synaptic cell adhesion molecules at the cell surface. Alternative splicing of cell adhesion molecules provides additional specificity in forming neuronal connections. For the teneurin family of cell adhesion molecules, alternative splicing of the EGF-repeats and NHL domain controls synaptic protein-protein interactions.

Sexual dimorphism in the social behaviour of Cntnap2-null mice correlates with disrupted synaptic connectivity and increased microglial activity in the anterior cingulate cortex.

A biological understanding of the apparent sex bias in autism is lacking. Here we have identified Cntnap2 KO mice as a model system to help better understand this dimorphism. Using this model, we observed social deficits in juvenile male KO mice only.

Cardiorespiratory kinetics in exercise physiology: estimates and predictions using randomized changes in work rate.

Purpose: Kinetics of cardiorespiratory parameters (CRP) in response to work rate (WR) changes are evaluated by pseudo-random binary sequences (PRBS testing). In this study, two algorithms were applied to convert responses from PRBS testing into appropriate impulse responses to predict steady states values and responses to incremental increases in exercise intensity.

Methods: 13 individuals (age: 41 ± 9 years, BMI: 23.

Confinement, partial sleep deprivation and defined physical activity-influence on cardiorespiratory regulation and capacity.

Introduction: Adequate cardiorespiratory fitness is of utmost importance during spaceflight and should be assessable via moderate work rate intensities, e.g., using kinetics parameters.