Publications by authors named "U D Staerz"
Article Synopsis
- Thymocyte positive and negative selection in the thymus depends on the strength of T-cell receptor (TCR) signals, with strong signals leading to negative selection and weak signals leading to positive selection.
- Researchers explored how the maturation stages of thymocytes influence their responses to different TCR signal strengths by studying them in a lab setting with thymic epithelial cells.
- The findings suggest a complex selection process where initial low-avidity TCR interactions promote positive selection, while subsequent higher-avidity interactions determine whether the thymocyte undergoes full maturation or negative selection.
Positive selection is a process that ensures that peripheral T cells express TCR that are self-MHC restricted. This process occurs in the thymus and requires both self-MHC and self-peptides. We have recently established a TCR transgenic (TCR(trans)(+)) mouse model using the C10.
View Article and Find Full Text PDFPositive selection is a process that ensures that peripheral T cells express TCR that are restricted to self-MHC molecules. This process requires both self-MHC and self-peptides. We have recently established a TCR transgenic mouse model (C10.
View Article and Find Full Text PDFLiposome encapsulated aurothiomalate reduces collagen-induced arthritis in DBA/1J mice.
Biochim Biophys Acta
September 1999
Collagen-induced arthritis (CIA) generated in rats or mice has long been a model system for the study of rheumatoid arthritis in humans. In particular, this system has been used to study the mechanisms and effects of anti-arthritic drugs in the treatment of the disease. Sodium aurothiomalate (ATM) is an agent often used to treat rheumatoid arthritis in humans; however, it possesses inherent toxicities which limits its usefulness.
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