Publications by authors named "U D Kahlert"
High expression of cellular self-activated immunosuppressive molecules and extensive infiltration of suppressive immune cells in the tumor microenvironment are the main factors contributing to glioma's resistance to immunotherapy. Nonetheless, technology to modify the expression of glioma cellular self-molecules through gene editing requires further development. This project advances cell therapy strategies to reverse the immunosuppressive microenvironment of glioma (TIME).
View Article and Find Full Text PDFBrain metastases (BrM) originating from lung and breast cancer can recruit and activate neutrophils to acquire a tumor-promoting phenotype. It is currently unclear if this phenomenon also occurs in BrM arising from other primary sites. Here, we investigated the effect of tumor cells isolated from melanoma, lung and gastrointestinal (GI) cancer BrM on neutrophil biology and functions.
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- A retrospective study assessed the diagnostic effectiveness of C-reactive protein (CRP) and leucocyte count in differentiating complicated (CAA) from uncomplicated acute appendicitis (UAA) based on EAES guidelines, involving 285 patients in Germany from 2019 to 2021.
- The study found that CRP levels were significantly higher in CAA patients compared to UAA patients, showing medium diagnostic value for identifying CAA and a cutoff at 44.3 mg/L, while leucocyte count had a low predictive value.
- Higher CRP levels were linked to an increased risk of postoperative complications and longer hospital stays, indicating that CRP is a useful marker for diagnosing CAA within the EA
Article Synopsis
- Glioblastoma (GBM) is a highly aggressive brain tumor, with a subtype called mesenchymal (MES-GBM) known for its resistance to treatment.
- Trihexyphenidyl (THP), an existing medication, has been shown to effectively inhibit the growth and survival of MES-GBM cells while sparing non-tumor cells.
- The study suggests THP's potential for repurposing as a cancer treatment, but more research is needed to clarify its mechanisms of action and establish optimal treatment protocols.