Centellicum® improves scarring of traumatic wounds with irregular edges (lacerations).

Background: Centellicum, a standardized Centella Asiatica extract, has been used orally for fibrosis and scar prevention. The main aim of this 2-month registry pilot study was the reduction of visible, significant scars and keloids after suturing traumatic wounds with irregular edges (lacerations), using Centellicum.

Methods: The effects of oral Centellicum (450 mg/day; 2 capsules) and a standard management (SM) on wound healing were compared with the effects of a control group that used only the standard management.

Pycnogenol® relieves chronic venous insufficiency (CVI) in diabetics: a supplement registry study.

Background: The aim of this supplement registry study was to evaluate the efficacy of Pycnogenol in controlling signs and symptoms of chronic venous insufficiency (CVI), diabetic microangiopathy and microcirculatory parameters - in diabetic patients with CVI and microangiopathy. These CVI patients are eligible for medical procedures as their incompetent superficial veins can be treated with repeated sclerotherapy and or local surgery according to needs.

Methods: During this registry study, only non-interventional managements were used.

Pycnogenol® + Centellicum® supplementation improves skin elasticity and microperfusion. Implication for surgical patients: a conceptual registry study.

Background: The aim of this registry study was to evaluate the effects of Pycnogenol and Centellicum (PYCE) on skin perfusion and skin elasticity in healthy women over a period of 4 weeks.

Methods: The supplemented women used 150 mg of Pycnogenol and 450 mg of Centellicum daily. The supplemented group used the combination PYCE daily for 4 weeks and followed the standard management (SM) in addition.

Pycnogenol® supplementation to relieve symptoms after hemorrhoidectomy.

Background: Hemorrhoids are a common problem associated with symptoms, like swelling, local thrombosis and generally with a decreased quality of life, often in otherwise healthy subjects. Hemorrhoids can be classified by grades (I to IV) according to their severity. In this registry study subjects treated with excisional hemorrhoidectomy (EH) for the first time, were included.

Pycnogenol® prevents skin hyperpigmentation following sclerotherapy.

Background: The aim of this registry supplement study was to evaluate the effects of the oral supplement Pycnogenol on possible skin discolorations or other minor skin changes after varicose vein sclerotherapy in comparison with a standard management (SM).

Methods: One hundred sixty-one subjects completed the study. 84 took Pycnogenol from the day before sclerotherapy for 12 weeks and followed SM.