Evaluation of a multimodal ctDNA-based assay for detection of aggressive cancers lacking standard screening tests.

Cancers lacking standard screening (LSS) options account for approximately 70% of cancer-related deaths due to late-stage diagnosis. Circulating tumor DNA (ctDNA) is a promising biomarker for multi-cancer early detection. We previously developed SPOT-MAS, a multimodal ctDNA-based assay analyzing methylation and fragmentomic profiles, effective in detecting common cancers (breast, colorectal, liver, lung and gastric).

Chemical screens for particle-induced macrophage death identifies kinase inhibitors of phagocytosis as targets for toxicity.

Background: Nanoparticles are increasingly being used in medicine, cosmetics, food, and manufacturing. However, potential toxicity may limit the use of newly engineered nanoparticles. Prior studies have identified particle characteristics that are predictive of toxicity, although the mechanisms responsible for toxicity remain largely unknown.

Detecting jingle and jangle fallacies by identifying consistencies and variabilities in study specifications - a call for research.

Over the past few years, more attention has been paid to jingle and jangle fallacies in psychological science. Jingle fallacies arise when two or more distinct psychological phenomena are erroneously labeled with the same term, while jangle fallacies occur when different terms are used to describe the same phenomenon. Jingle and jangle fallacies emerge due to the vague linkage between psychological theories and their practical implementation in empirical studies, compounded by variations in study designs, methodologies, and applying different statistical procedures' algorithms.

BICC1 Interacts with PKD1 and PKD2 to Drive Cystogenesis in ADPKD.

Background: Autosomal dominant polycystic kidney disease (ADPKD) is primarily of adult-onset and caused by pathogenic variants in or . Yet, disease expression is highly variable and includes very early-onset PKD presentations or infancy. In animal models, the RNA-binding molecule Bicc1 has been shown to play a crucial role in the pathogenesis of PKD.