Secondary nucleation guided noncovalent synthesis of dendritic homochiral superstructures via growth on and from surface.

Secondary nucleation is an emerging approach for synthesizing higher-order supramolecular polymers with exciting topologies. However, a detailed understanding of growth processes and the synthesis of homochiral superstructures is yet to be demonstrated. Here, we report the non-covalent synthesis of dendritic homochiral superstructures using NIR triimide dyes as building blocks via a secondary nucleation elongation process.

A review on chitosan-based membranes for sustainable CO separation applications: Mechanism, issues, and the way forward.

Effective carbon dioxide (CO) separation by nominal energy utilization is the factual attempt in the present era of energy scarcity and environmental calamity. In this perspective, the membrane- based gas separation technology is a budding endeavour owing to its cost -effectiveness, ease of operational maintenance and compact modular design. Among various membrane materials, bio-based polymers are of interest as they are abundant and can be obtained from renewable resources, and can also reduce our dependency on exhaustible fossil fuel-based sources.

Global shapes of F-actin depolymerization-competent minimal gelsolins: insight into the role of g2-g3 linker in pH/Ca2+ insensitivity of the first half.

Because of its ability to rapidly depolymerize F-actin, plasma gelsolin has emerged as a therapeutic molecule in different disease conditions. High amounts of exogenous gelsolin are, however, required to treat animal models of different diseases. Knowing that the F-actin depolymerizing property of gelsolin resides in its N terminus, we made several truncated versions of plasma gelsolin.

A communication network within the cytoplasmic domain of toll-like receptors has remained conserved during evolution.

Toll/IL-1R (TIR) domain, that is, the cytoplasmic domain, in toll-like receptors (TLRs) from different species showed high sequence conservation in stretches spread across the surface as well as the core of the domain. To probe the structure-function significance of these residues, especially those coming from the core of TIR domains, we analyzed molecular dynamics trajectories of sequence similarity based models of human TIR domains. This study brought forth that N-terminal of the TIR domain simultaneously interacts with the flanking residues of the BB loop and central β-sheets.

Amlodipine-induced gingival hyperplasia.

Gingival hyperplasia can occur during use of drugs such as diphenylhydantoin, cyclosporine and nifedipine. We report, three cases of gingival hyperplasia induced by amlodipine, a second generation calcium channel blocker. Exact cause of induction of thehyperplasia is not known.