Publications by authors named "U Bang"
Article Synopsis
- - The XBB sub-variants FL.1 and GE.1 of SARS-CoV-2 are spreading globally, raising concerns about their ability to evade the immune system due to mutations in the spike protein.
- - A study evaluated eleven FDA-approved monoclonal antibody combinations against various Omicron variants, revealing that Sotrovimab was the most effective against XBB.1.5 but less so against the newer sub-lineages FL.1 and GE.1.
- - The results highlight a stronger immune evasion ability in these emerging XBB variants, stressing the importance of ongoing surveillance for novel SARS-CoV-2 variants.
Dual CRISPR-Cas3 system for inducing multi-exon skipping in DMD patient-derived iPSCs.
Stem Cell Reports
September 2023
To restore dystrophin protein in various mutation patterns of Duchenne muscular dystrophy (DMD), the multi-exon skipping (MES) approach has been investigated. However, only limited techniques are available to induce a large deletion to cover the target exons spread over several hundred kilobases. Here, we utilized the CRISPR-Cas3 system for MES induction and showed that dual crRNAs could induce a large deletion at the dystrophin exon 45-55 region (∼340 kb), which can be applied to various types of DMD patients.
View Article and Find Full Text PDFSelection-free, scarless genome editing in human pluripotent stem cells (PSCs) by utilizing ribonucleoprotein (RNP) of CRISPR-Cas9 is a useful tool for a variety of applications. However, the process can be hampered by time-consuming subcloning steps and inefficient delivery of the RNP complex and ssDNA template. Here, we describe the optimized protocol to introduce a single nucleotide change or a loxP site insertion in feeder-free, xeno-free iPSCs by utilizing MaxCyte and 4D-Nucleofector electroporators.
View Article and Find Full Text PDFHepatotoxicity induced by a second-generation combined oral contraceptive: case report and review of the literature.
Eur J Contracept Reprod Health Care
August 2019
Second-generation combined oral contraceptives (COCs) are widely used and are believed to be safe for birth control and in the treatment of gynaecological diseases. No randomised controlled study has shown elevations in alanine transaminase (ALT) levels in relation to the use of a second-generation COC. We report a case of drug-induced liver injury (DILI) in a young, moderately obese woman, due to the use of a second-generation COC containing 30 µg ethinylestradiol and 150 µg levonorgestrel.
View Article and Find Full Text PDFObjectives: Chronic pancreatitis (CP) is associated with a shortened life expectancy. Statins have anti-inflammatory properties and we aimed to evaluate the association between the use of statins and the risk of death, progression of CP, and pancreatic cancer in patients with CP.
Patients And Methods: We carried out a nested case-cohort study and included patients with CP.