Tissue and serum levofloxacin concentrations in diabetic foot infection patients.

Objectives: Levofloxacin has a high bioavailability and a broad antibacterial spectrum which covers the common pathogens found in acute and chronic diabetic foot infections. The purpose of our study was to determine the serum and tissue concentrations of levofloxacin when administered orally in patients with infected diabetic foot ulcers and to compare these values with microbiological findings.

Patients And Methods: Ten outpatients with diabetes and ulcerations of the lower extremity were included.