Publications by authors named "U BAUMGARTNER"
Glioblastoma is characterized by a pronounced resistance to therapy with dismal prognosis. Transcriptomics classify glioblastoma into proneural (PN), mesenchymal (MES) and classical (CL) subtypes that show differential resistance to targeted therapies. The aim of this study was to provide a viable approach for identifying combination therapies in glioblastoma subtypes.
View Article and Find Full Text PDFRecurrence is the primary life-threatening complication for medulloblastoma (MB). In Sonic Hedgehog (SHH)-subgroup MB, OLIG2-expressing tumor stem cells drive recurrence. We investigated the anti-tumor potential of the small-molecule OLIG2 inhibitor CT-179, using SHH-MB patient-derived organoids, patient-derived xenograft (PDX) tumors and mice genetically-engineered to develop SHH-MB.
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- Adult-type diffuse gliomas, particularly those classified as CNS WHO grade 4, are highly aggressive brain tumors that pose significant challenges for treatment; this study analyzed their genetic and molecular changes after recurrence.
- The research involved sequencing and profiling to uncover alterations in recurrent gliomas, revealing that 75% of patients had early branching evolution, along with changes in mutational patterns and increased TGF-β signaling.
- Findings indicate that TGF-β plays a critical role in the recurrence of gliomas and could guide future therapies, particularly with TGF-β inhibitors potentially aiding in overcoming resistance to chemoradiation treatments.
Simultaneous EEG/MEG yields complementary information of nociceptive evoked responses.
Clin Neurophysiol
November 2022
Objective: Nociceptive stimuli have been studied either by dipolar modelling using electroencephalography (EEG) or magnetoencephalography (MEG), but rarely using both techniques simultaneously. This study aims to investigate the spatiotemporal representation of cortical activity in response to non-nociceptive (tactile) and nociceptive (laser) stimuli using parallel EEG-MEG recordings.
Methods: We performed simultaneous EEG and MEG recordings in 12 healthy subjects by applying pneumatic tactile and nociceptive laser stimuli on the right- and left-hand dorsum.
Nerve conduction studies (NCS) are an essential aspect of the assessment of patients with peripheral neuropathies. However, conventional NCS do not reflect activation of small afferent fibers, including Aδ and C fibers. A definitive gold standard for laboratory evaluation of these fibers is still needed and therefore, clinical evaluation remains fundamental in patients with small fiber neuropathies (SFN).
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