The neuropathology of trimethyltin in the marmoset (Callithrix jacchus) hippocampal formation.

The effects of single and repeated doses of trimethyltin (TMT) treatment on the central nervous system (CNS) of the marmoset were investigated. For the acute-dose experiment adult animals were administered 3 mg/kg of TMT chloride (ip) and were then observed for changes in behavior. Within 24 hr postinjection all animals developed tremors, ataxia, and unresponsiveness.

Damage and repair of mouse bronchial epithelium following acute inhalation of trichloroethylene.

The time-course of damage and repair in the bronchial epithelium of the mouse was studied morphometrically after a single inhalation of trichloroethylene (TCE). Mice were exposed for 30 min to 500, 1000, 2000, 3500, or 7000 ppm of TCE under controlled conditions and sacrificed after 2 and 24 h, and 2, 5, and 7 days. At all TCE concentrations, the damage consisted of dilation of endoplasmic reticulum and was selective for nonciliated cells throughout the bronchial tree.

Reciprocal translocations in ageing mice and in mice with long-term low-level 239Pu contamination.

Single intravenous injections of 185 Bq monomeric 239Pu were given to male mice, and the frequency of primary spermatocytes with reciprocal translocations, determined 724 days after treatment, was not significantly different from that of age-matched untreated controls. These old animals showed significantly higher aberration frequencies than young adults. The data therefore show that for low initial activity and very long retention time the possible cytogenetic effects of incorporated nuclide does not change the age-related pattern of increase of spontaneous chromosome aberrations.

Long-term 238Pu and 239Pu retention and organ distribution in mice at low doses.

The 238Pu and 239Pu distribution in femur, liver, kidneys and testes and the retention function in the skeleton and liver have been studied in about 50 (C57 BL X C3H) F1 male mice. Groups of about 5-10 male mice were sacrificed from 10 to 800 days postinjection to cover their entire life span. All animals were injected intravenously with monomeric solutions of plutonium (1% trisodium citrate at pH 6.

The relationship between o.e.r., r.b.e. and number of fractions for X-ray- or neutron-induced skin damage.

The skin reactions in aerated and hypoxic mouse tails after single or fractionated doses of 250 kV X-rays or fast neutrons (6 MeV deuterons on beryllium) have been measured. The o.e.