Publications by authors named "U Altes"
Background: Treatment modalities of renal replacement therapy differ in their diffusive and convective mass transfer characteristics. It was the goal of this study to clarify whether an increase in convective mass transfer as performed with haemofiltration (HF) and haemodiafiltration (HDF) in comparison with high-flux haemodialysis (HD) is associated with an alteration in procoagulatory activity or with complement activation.
Methods: Ten stable chronic HD patients were monitored during 120 treatments in a randomized cross over design.
Rheopheresis is a specific application of membrane differential filtration, synonymous with double filtration plasmapheresis, for extracorporeal hemorheotherapy. Safety and efficacy of Rheopheresis for wound healing and skin oxygenation were investigated in patients with ischemic diabetic foot syndrome. Eight patients with type 2 diabetes mellitus and non-healing foot ulcers caused by severe ischemic diabetic foot syndrome were treated by a series of seven Rheopheresis sessions in a time span of 11 weeks.
View Article and Find Full Text PDFBackground/aims: Antibodies to cytochrome P450 2D6, also known as LKM1-autoantibodies, are characteristic for a subgroup of patients with autoimmune hepatitis, but can also occasionally be found in hepatitis C. We observed the occurrence of LKM1-autoantibodies 4 months after liver transplantation for Wilson's disease, in close association with a steroid-resistant rejection episode, in the absence of evidence for autoimmune hepatitis or hepatitis C.
Methods: Sera from several time points prior to and following transplantation were tested for LKM-reactivity by immunofluorescence, ELISA and Western blotting.
A muscarinic receptor different from the M1, M2, M3 and M4 subtypes mediates the contraction of the rabbit iris sphincter.
Naunyn Schmiedebergs Arch Pharmacol
June 1992
Article Synopsis
- The study investigates the specific subtype of muscarinic receptors involved in muscle contractions induced by methacholine in the rabbit iris sphincter by measuring equilibrium dissociation constants (KB) of various antagonists.
- The antagonists showed varying affinities, with results suggesting the presence of an M2 receptor in the muscle, as evidenced by competitive antagonism patterns.
- The findings imply that other muscarinic receptors (M1, M3, M4) are unlikely present, while low affinity values and a specific enantiomeric ratio could indicate the potential involvement of an M5 receptor.