Locomotor Activity Monitoring in Mice to Study the Phase Shift of Circadian Rhythms Using ClockLab (Actimetrics).

The circadian clock regulates biochemical and physiological processes to anticipate changes in light, temperature, and food availability over 24 h. Natural or artificial changes in white/blue lighting exposure (e.g.

Cyclin-dependent kinase 5 (Cdk5) activity is modulated by light and gates rapid phase shifts of the circadian clock.

The circadian clock enables organisms to synchronize biochemical and physiological processes over a 24 hr period. Natural changes in lighting conditions, as well as artificial disruptions like jet lag or shift work, can advance or delay the clock phase to align physiology with the environment. Within the suprachiasmatic nucleus (SCN) of the hypothalamus, circadian timekeeping and resetting rely on both membrane depolarization and intracellular second-messenger signaling.

Arginase-II gene deficiency reduces skeletal muscle aging in mice.

Age-associated sarcopenia decreases mobility and is promoted by cell senescence, inflammation, and fibrosis. The mitochondrial enzyme arginase-II (Arg-II) plays a causal role in aging and age-associated diseases. Therefore, we aim to explore the role of Arg-II in age-associated decline of physical activity and skeletal muscle aging in a mouse model.

Achieving Digital Medicine Learning Outcomes Through an Interdisciplinary Course: A Pilot Study.

Incorporating digital medicine into medical education equips students for the evolving landscape of healthcare. This study aimed to assess a digital medicine course developed at Bielefeld University by evaluating student attainment of learning outcomes outlined by Foadi et al. In the course, the students designed a digital application for various medical conditions, taking into account interdisciplinary factors.