Effect of clomipramine on monoamine metabolites in the cerebrospinal fluid of behaviorally normal dogs.

The tricyclic antidepressant, clomipramine, is an effective treatment for canine compulsive disorder (canine CD). This disorder is a clinical syndrome of abnormal conflict behaviors and its pathophysiology is unknown. However, because clomipramine is an effective treatment, information about the drug's neurochemical effect could enhance the understanding of canine CD.

A cross-sectional study on compulsive behaviour (stable vices) in horses.

A researcher-administered survey study was performed involving 769 horses from 32 Thoroughbred, Standardbred, and pleasure horse stables in southwestern Ontario. Data were gathered on individuals (breed, age, and sex) and at the stable level (housing, management). The effects of these factors on cribbing, stall-walking, weaving, stall-kicking, tongue playing, and pawing were assessed by unconditional analysis (Chi-square, t test) and conditionally using stepwise logistic regression.

The use of chance-corrected agreement to diagnose canine compulsive disorder: an approach to behavioral diagnosis in the absence of a 'gold standard'.

This study assessed the diagnostic accuracy of formal diagnostic criteria for canine compulsive disorder (canine CD). Canine CD is a syndrome of abnormal behaviors that are believed to result from conflict or frustration. Differential diagnoses include normal conflict behavior and learned behavior.

Efficacy of clomipramine in the treatment of canine compulsive disorder.

Objective: To assess the efficacy of clomipramine for treatment of canine compulsive disorder (CCD).

Design: Randomized, placebo-controlled, double-blind, balanced AB-BA crossover clinical study.

Animals: 51 dogs with CCD.

The pharmacokinetics of clomipramine and desmethylclomipramine in dogs: parameter estimates following a single oral dose and 28 consecutive daily oral doses of clomipramine.

Clomipramine is a tricyclic antidepressant that has been recommended for the treatment of canine compulsive disorder. The pharmacokinetics of clomipramine in dogs have not been reported. This study describes the pharmacokinetics of clomipramine and its active metabolite, desmethylclomipramine, in six male dogs.