Publications by authors named "TzuMin Chen"
Glioblastoma multiforme (GBM) is a brain cancer characterized by low survival and high recurrence rates. Farnesoid X receptor (FXR), a nuclear receptor for bile acids, is expressed at low levels in GBM. This study explores the impact of FXR regulation on GBM cell migration and invasion.
View Article and Find Full Text PDFGlioblastoma multiforme (GBM) is a deadly type of brain tumor with low patient survival rates. Previous studies have shown that inhibiting the intracellular bile acid transport protein can suppress brain tumor growth, migration, and angiogenesis. This study aims to investigate the effects of the bile acid nuclear receptor (farnesoid X receptor, FXR) agonist GW4064 on the migration, and invasion in GBM cells.
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- Bladder cancer is more common in men and has high recurrence rates, particularly for non-muscle-invasive forms.
- Transient receptor potential canonical channels (TRPCs), especially TRPC3, influence cancer cell behavior through calcium signaling, and the study investigates the effects of the TRPC3 inhibitor Pyr3 on bladder cancer cells.
- Pyr3 treatment led to reduced cell viability, migration, and specific protein levels associated with cancer progression, indicating its potential as a therapeutic agent for bladder cancer by targeting PKC signaling.
Article Synopsis
- * PSMB4 is found to be highly expressed in both low- and high-grade bladder cancer, and its knockdown leads to reduced migration of cancer cells by decreasing proteins like focal adhesion kinase (FAK) and myosin light chain (MLC).
- * In addition to affecting cancer cell movement, knocking down PSMB4 lowers levels of vascular endothelial factor B (VEGF-B), which decreases blood vessel formation, showing PSMB4 as a promising target for treatments against bladder cancer.
The ability of bladder cancer to invade and metastasize often leads to poor prognosis in bladder cancer patients. The aim of this study was to evaluate the effect of the farnesoid X receptor (FXR) agonist GW4064 on the migration and invasion of human bladder cancer cells. Long-term exposure to GW4064 decreased the colony formation of RT4 and T24 cells.
View Article and Find Full Text PDFGlioblastoma multiforme (GBM) is a deadly brain malignancy, and current therapies offer limited survival benefit. The phytosterol guggulsterone (GS) has been shown to exhibit antitumor efficacy. This study aimed to investigate the effects of GS on migration and invasion and its underlying mechanisms in human GBM cell lines.
View Article and Find Full Text PDFGlioblastoma is believed to be one of the most aggressive brain tumors in the world. ONX-0914 (PR957) is a selective inhibitor of proteasome subunit beta type-8 (PSMB8). Previous studies have shown that inhibiting PSMB8 expression in glioblastoma reduces tumor progression.
View Article and Find Full Text PDFBladder cancer is one of the most prevailing cancers worldwide. Although treatments for urothelial carcinoma have improved, the rate of recurrence observed in the clinic is still high. The aim of this study was to evaluate whether cholesterol biosynthesis is involved in the effect of Farnesoid X Receptor (FXR) on bladder cancers.
View Article and Find Full Text PDFLung cancer-related pleural fluid (LCPF) presents as a common complication with limited treatment. Beyond its function in lipid digestion, bile acid was identified as a potent carcinogen to stimulate tumor proliferation. Previous research indicated a correlation between serum bile acid levels and the risk of developing several gastrointestinal cancers.
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