Exploring the biphasic dose-response effects of photobiomodulation on the viability, migration, and extracellular vesicle secretion of human adipose mesenchymal stem cells.

Photobiomodulation (PBM) is a well-established medical technology that employs diverse light sources like lasers or light-emitting diodes to generate diverse photochemical and photophysical reactions in cells, thereby producing beneficial clinical outcomes. In this study, we introduced an 830 nm near-infrared (NIR) laser irradiation system combined with a microscope objective to precisely and controllably investigate the impact of PBM on the migration and viability of human adipose mesenchymal stem cells (hADSCs). We observed a biphasic dose-response in hADSCs' viability and migration after PBM exposure (0-10 J/cm), with the 5 J/cm group showing significantly higher cell viability and migration ability than other groups.

Responses to booster hepatitis B vaccination are significantly correlated with genotypes of human leukocyte antigen (HLA)-DPB1 in neonatally vaccinated adolescents.

Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) near the human leukocyte antigen (HLA)-DP loci that were significantly correlated with outcomes of hepatitis B virus (HBV) infection. We performed a case-control study nested in a well-characterized cohort of booster recipients to assess whether genetic variants of HLA-DPB1 are also associated with response to hepatitis B (HB) vaccination. The cases and controls were 171 and 510 booster recipients whose post-booster titers of antibodies against HBV surface antigen (anti-HBs) were undetectable and detectable, respectively.

Prevalence and determinants of SENV viremia among adolescents in an endemic area of chronic liver diseases.

Background: SENV is a potential causative agent responsible for chronic liver diseases (CLDs) that are precipitated in early life. SENV prevalence in adolescents is unknown and its transmission route is uncertain.

Methods: We randomly selected 824 serum samples from a cohort of 2383 adolescents aged 15-17 years who resided in Hualien County, an endemic area of liver diseases.

Geographic and ethnic variations of long-term efficacy and immunogenicity of hepatitis B vaccination in Hualien, a HBV hyperendemic area.

It is uncertain whether immunologic memory persists for 15 years or more after immunization and whether the efficacy of universal hepatitis B vaccination program (UHBVP) in socio-economically disadvantaged area with hyperendemicity of hepatitis B virus (HBV) infection is similar. We assayed hepatitis B surface antigen (HBsAg) and antibody to HBsAg (anti-HBs) on 2839 students aged 15 years or more born before (N = 248) and after (N = 2591) UHBVP. We found that students born after UHBVP had significantly lower positive rate of anti-HBs than those born before UHBVP (44.